By Hugo Daniel in Kentucky
He's dated a string of the world's most beautiful women.
But rumours about his sexuality have continued to follow George Clooney.
Now his sister Adelia Zeidler has set the record straight in her first ever interview - insisting her little brother is not gay.
Asked what she makes of rumours that her brother is secretly gay, the 52-year-old laughed and said: 'Yes that’s quite ridiculous, we don’t even listen when people say things like that anymore.
'I think he decided that in his life he could have the career or he could have a family and so when he decided to go full bore into the acting, that was where his focus was going to be.'
In fact Ada revealed that George has found it easy to bag pretty girls since his high school days.
She said: 'Well he had several girlfriends when he was going to high school down here. Never more than one at a time, he’s not that kind of guy.
'But he would go out with someone for a few months and then go out with someone else for a few months.
'He had longer hair in high school, it was more blonde, it didn’t really get dark until he was about 16 or so. And he was always very funny and girls like to laugh.
‘I think he was always pretty fair and honest with the girls he went out with.
'I don’t recall any of them feeling as though he had just broken their heart and dumped them unexpectedly, I think most of the relationships came to a kind of natural close. I don’t recall any angry phone calls or anything like that.'
But while she insists her brother is not gay, Adelia thinks it unlikely that he will marry his current girlfriend, Stacy Keibler.
Speaking from her home in Augusta, Kentucky, where they grew up, Adelia said: 'No I would say he probably will not get married.
'If I had to guess I would have to say no. I know everyone says "well Warren Beatty said he’d never get married and then he met Annette Bening" but you know that’s the only example people can think of, so it doesn’t bode too well.'
George was once married to actress Talia Balsam but the two divorced in 1993.
Since then he’s had a string of gorgeous girlfriends including British model Lisa Snowdon, Italian beauty Elisabetta Canalis and currently Stacy - a stunning blonde actress and former wrestler.
Explaining her logic, Adelia, who goes by Ada, added: 'If he was going to get married he would want to be a husband and be somebody who would be there, who would have the time and the ability to focus on the family and the wife and the home and all of that.
'And in the business that he is in he has to be able to get up and go. The majority of actors don’t really make their marriages work.'
In fact Ada thinks for that same reason George, 51, will also never have children.
She explained: 'If he had children, when he was with them he would be concerned about his career and if he was working he would be concerned about the children and he doesn’t think it would be fair to split his focus.'
Recalling his first wedding, Ada confesses George didn’t even tell her he was married until after it happened.
She said: 'No I didn’t go. Yes it was [a quick thing]. I was not aware he was married until after he was married.
'I knew that they were thinking of it and all of that, but I believe the actual timing was a quick decision.'
Asked if their parents Nick and Nina - who also live in Augusta down the road from Ada - long for George to tie the knot again, Ada added: 'They think it’s his own business.
'None of us worry or wonder too much about it, he either will or he won’t. If we had to guess we’d say no.'
Even though George and Ada were born just one year and four days apart – it would be almost impossible to guess that they are brother and sister now. In fact she couldn't be more different from the well-groomed A-lister.
The full-time mum sports a rather unkempt appearance as she goes about her daily chores cleaning her home, feeding the children and giving them lifts in a battered old 80s-style Volvo with a broken headlight.
However the mother-of-two did find it very strange when her brother was crowned World’s Sexiest Man by People magazine.
She said: 'It is rather odd to see my baby brother being touted as the World’s Sexiest man - I have a little difficulty seeing that. Granted I can look at him and see he’s very attractive but of course being his sister it’s a little odd.
'I think he rather enjoyed getting teased about it (by the family).'
George and Ada’s aunt was the famous American singer and actress Rosemary Clooney and their dad Nick was a TV news anchorman– so showbusiness was very much in their blood.
And although both siblings took an early interest in acting, appearing in many school plays, it was George who decided to take the gamble and go off to Hollywood to follow his dreams.
Meanwhile Ada got married and had two children - Jennifer, now 21, and Nicholas, now 16 – while holding down different bookkeeping jobs.
Her cheeky younger brother used to tease her about wanting to be like June Cleaver, a 1950s sitcom character seen as the archetypal suburban mum.
She said: 'I worked at Toys R Us and Kohl’s. I enjoyed it, but mostly it was a way to get the money to come home and pay the rent and those sorts of things. I really enjoyed being a wife and a mother and that kind of wound up taking precedence with me.'
Tragically Ada’s husband Norman, an artist, died suddenly of a heart attack in 2004 aged just 47 and she had to quit work to look after the children full time.